Valvex A (80/5)/Valvex A (160/5)/Valvex A (160/10) Dosage/Direction for Use

The recommended dose of Valsartan+Amlodipine (VALVEX A) is one tablet per day. Valsartan 80 mg/Amlodipine 5 mg may be administered in patients whose blood pressure is not adequately controlled with amlodipine 5 mg or valsartan 80 mg alone.
Valsartan160 mg/Amlodipine 5 mg may be administered in patients whose blood pressure is not adequately controlled with amlodipine 5 mg or valsartan 160 mg alone.
Valsartan 160 mg/Amlodipine 10 mg may be administered in patients whose blood pressure is not adequately controlled with amlodipine 10 mg or valsartan 160 mg alone or with Valsartan 160 mg/Amlodipine 5 mg.
Valsartan+Amlodipine (VALVEX A) can be used with or without food.
Individual dose titration with the components (i.e. amlodipine and valsartan) is recommended before changing to the fixed dose combination. When clinically appropriate, direct change from monotherapy to the fixed-dose combination may be considered.
For convenience, patients receiving valsartan and amlodipine from separate tablets/capsules may be switched to Valsartan+Amlodipine (VALVEX A) containing the same component doses.
Renal impairment: Valsartan+Amlodipine (VALVEX A) is contraindicated in patients with severe renal impairment. No dosage adjustment is required for patients with mild to moderate renal impairment. Monitoring of potassium levels and creatinine is advised in moderate renal impairment.
Hepatic impairment: Valsartan+Amlodipine (VALVEX A) is contraindicated in patients with severe hepatic impairment Caution should be exercised when administering Valsartan+Amlodipine (VALVEX A) to patients with hepatic impairment or biliary obstructive disorders. In patients with mild to moderate hepatic impairment without cholestasis, the maximum recommended dose is 80 mg valsartan. Amlodipine dosage recommendations have not been established in patients with mild to moderate hepatic impairment.
Elderly (age 65 years or over): In elderly patients, caution is required when increasing the dosage.
Paediatric population: The safety and efficacy of Valsartan+Amlodipine (VALVEX A) in children aged below 18 years have not been established. No data are available.
Method of Administration: Oral use. It is recommended to take Valsartan+Amlodipine (VALVEX A) with some water.